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The population is more active and living longer and fifty active years after fifty, over 100 million steps is an expectation for many people. Our bones and joints start to deteriorate in middle age and joint pain and osteoarthritis now affects more than 15% of the population. Surgical interventions are often needed to enable people to stay active. Advances in medical engineering and in biomaterials, now allow us to design artificial joint replacements, with real expectations of meeting the lifetime needs of active patients in their fifties and sixties. These joint replacements have been developed with advanced engineering computer assisted design, simulation and enhanced pre-clinical testing to deliver increased reliability and lifetimes. In the last ten years advances in biological sciences research has allowed us to develop new technologies in the form of novel biological scaffolds which encourage the body to regenerate itself with its own cells. These are now entering clinical trials. This unique story describes how advances in engineering and biology have combined to offer the potential for early and minimally invasive interventions to repair and regenerate tissues in the musculoskeletal system and deliver fifty active years after fifty®.
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